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Product name : Nexturastat A
Item : CR1924
Price : 100mg, $695; 200mg, $1095;
contact : Send inquiry to: info@acesobio.com
Additional Information :  We offer significant discount for bulky quantity order,Please ask price and availability of other quantities
CAS : 1403783-31-2
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Details:
 

Chemical Information

M.Wt 341.4 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C19H23N3O3
CAS No 1403783-31-2
Solubility

DMSO > 60 mg/ml



Biological Activity of Nexturastat A

 

Nexturastat A is a potent and selective HDAC6 inhibitor with IC50 of 5 nM; no inhibition on other HDAC forms.
IC50 value: 5 nM [1]
Target: HDAC6 inhibitor
Nexturastat A displayed low micromolar activity compared to the low nanomolar activity against HDAC6. Moreover, it also demonstrated high levels of selective inhibition against members of the related Class 2 HDAC isozymes reaching >1000-fold selective in some cases. Compared to the pan-selective HDACI LBH589, Nexturastat A is approximately 100-fold less potent in inducing murine B16 melanoma cell death.

 

[1]. Bergman JA, et al. Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. J Med Chem. 2012 Nov 26;55(22):9891-9.


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