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Product name : CNX-1351
Item : CR1845
Price : 100mg, $745; 200mg, $1285
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CAS : 1276105-89-5
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Details:
 Name:  CNX-1351

CAS#: 1276105-89-5

Chemical Formula: C30H35N7O3S
Exact Mass: 573.25221
Molecular Weight: 573.71
Elemental Analysis: C, 62.81; H, 6.15; N, 17.09; O, 8.37; S, 5.59


Description of  CNX-1351:  CNX-1351 is a selective covalent Inhibitor of PI3Kα.  In an end point assay, CNX-1351 potently inhibited PI3Kα and was 20−400 times less potent against β, γ, and δ. CNX-1351 inhibit PI3Kα signaling in cells and shows prolonged inhibition consistent with a covalent mechanism of Action. CNX-1351 inhibits growth of cells dependent on PI3Kα.  CNX-1351 also inhibits PI3Kα signaling in vivo and bonds to p110α.



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