Favorite  |  Set Home
Products > Others > > ATB 346
Product name : ATB 346
Item : CR1834
Price : 200mg, $659;500mg, $1150; 1g, $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com
CAS : 1226895-20-0
Molecular Weight : 365.45
Formula : C₂₁H₁₉NO₃S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
 Chemical Information
M.Wt 365.45 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C21H19NO3S
CAS No 1226895-20-0
Solubility

DMSO



Biological Activity of ATB-346

 

ATB-346 is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.
IC50 value:
Target: COX-2
ATB-346 suppressed gastric prostaglandin E(2) synthesis as effectively as naproxen, but produced negligible damage in the stomach and intestine, Unlike naproxen and celecoxib, ATB-346 accelerated healing of pre-existing gastric ulcers. In a mouse airpouch model, ATB-346 suppressed cyclooxygenase-2 activity and inhibited leukocyte infiltration more effectively than naproxen. ATB-346 was as effective as naproxen in adjuvant-induced arthritis in rats, with a more rapid onset of activity. Unlike naproxen, ATB-346 did not elevate blood pressure in hypertensive rats [1]. Treatement with ATB-346 exhibited a significantly more rapid and sustained recovery of motor function, achieving greater than double the increase in locomotion score of the naproxen group by the 10th day of treatment. ATB-346 also significantly reduced the severity of inflammation (proinflammatory cytokines, apoptosis of neural tissue, and nitrosative stress) that characterized the secondary effects of SCI [2].

 

[1]. Wallace JL, et al. Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346). Br J Pharmacol. 2010 Mar;159(6):1236-46.

[2]. Campolo M, et al. A hydrogen sulfide-releasing cyclooxygenase inhibitor markedly accelerates recovery from experimental spinal cord injury. FASEB J. 2013 Nov;27(11):4489-99.


Related Products :
(+) Etomoxir sodium salt
(+) Etomoxir sodium salt
Price: 200mg, $1750;500mg, $2690; 1g $3590; 2g, $5190
Zafirlukast
Zafirlukast
Price: 1g, $490
TH302
TH302
Price: 200mg, $1250;500mg, $2090; 1g, $2995;
Febuxostat
Febuxostat
Price: 5g, $650;10g, $1050; 20g $1650
Lesinurad sodium
Lesinurad sodium
Price: 1g, $650;2g, $1050;
D-Luciferin (Synonyms: D-(-)-Luciferin; Firefly luciferin)
D-Luciferin (Synonyms: D-(-)-Luciferin; Firefly luciferin)
Price: 200mg, $659;500mg, $1150; 1g, $1595; 2g, $2355
BIX 01294
BIX 01294
Price: 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
Netobimin
Netobimin
Price: 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355