Favorite  |  Set Home
Products > Others > > Atglistatin
Product name : Atglistatin
Item : CR1814
Price : 200mg, $945;500mg, $1485
contact : Send inquiry to: info@acesobio.com
Additional Information :  We offer significant discount for bulky quantity order,Please ask price and availability of other quantities
CAS : 1469924-27-3
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
 Chemical Information
M.Wt 283.37 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C17H21N3O
CAS No 1469924-27-3
Solubility

DMSO up to 100 mM



Biological Activity of Atglistatin

 

Atglistatin is a highly potent, selective and competitive inhibitor of adipose triglyceride lipase (ATGL) with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, but no toxicity up to a concentration of 50 μM.
IC50 value: 0.7 uM [1]
Target: ATGL
Atglistatin inactivated ATGL in the presence or absence of the ATGL co-activator CGI-58. It does not displace ATGL from lipid droplets of adipocytes. Immunoprecipitation experiments revealed that Atglistatin does not interfere with the interaction of ATGL and CGI-58. Atglistatin inhibited TG hydrolase activity of wild-type WAT in a dose-dependent manner up to 78% in animal models. It was highly effective in inhibiting lipolysis in WAT organ cultures of wild-type mice. Dose and time-dependent inhibition of lipolysis was also observed in fasted wild-type C57Bl/6J mice. Atglistatin can serve as a very useful tool compound to study the pathophysiology and druggability of ATGL in animal models of metabolic disease and cachexia [1].

 

[1]. Mayer N, et al. Development of small-molecule inhibitors targeting adipose triglyceride lipase. (2013) Nat Chem Biol. 9(12):785-7.
Abstract
Adipose triglyceride lipase (ATGL) is rate limiting in the mobilization of fatty acids from cellular triglyceride stores. This central role in lipolysis marks ATGL as an interesting pharmacological target as deregulated fatty acid metabolism is closely linked to dyslipidemic and metabolic disorders. Here we report on the development and characterization of a small-molecule inhibitor of ATGL. Atglistatin is selective for ATGL and reduces fatty acid mobilization in vitro and in vivo.


Related Products :
Ramelteon (TAK 375, Rozerem)
Ramelteon (TAK 375, Rozerem)
Price: 10mg, $325; 50mg,$1175; 100mg, $1695; 200mg,$2475
CCG 50014
CCG 50014
Price: 10mg, $125; 50mg, $495; 100mg, $795; 200mg, $1095
ICG 001
ICG 001
Price: 10mg, $195; 50mg, $795; 100mg,$1295; 200mg, $2155
CK-636
CK-636
Price: 200mg, $845; 500mg, $1485
Y320
Y320
Price: 100mg, $845; 200mg, $1285
N6022
N6022
Price: 100mg, $745; 200mg, $1185
P7C3-A20
P7C3-A20
Price: 100mg, $845; 200mg, $1285
5S rRNA modificator
5S rRNA modificator
Price: 100mg, $945; 200mg, $1485