Favorite  |  Set Home
Products > Others > > Y320
Product name : Y320
Item : CR1813
Price : 200mg, $750;500mg, $1290; 1g, $1990; 2g, $2995
contact : Send inquiry to: info@acesobio.com
CAS : 288250-47-5
Molecular Weight : 505.01
Formula : C₂₇H₂₉ClN₆O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
 Chemical Information
M.Wt 505.01 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C27H29ClN6O2
CAS No 288250-47-5
Solubility

DMSO



Biological Activity of Y-320

 

Y-320 is a new phenylpyrazoleanilide immunomodulator; inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM.
IC50 value: 20-60 nM (IL-17 production) [1]
Target: IL-17
Y-320 inhibited IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM. Oral administration of Y-320 (0.3 to 3 mg/kg) significantly inhibited the development and progression of arthritis and joint destruction with reduction of IL-17 mRNA expression in arthritic joints of type II collagen-induced arthritis (CIA) in DBA/1J mice. Y-320 in combination with anti-murine tumor necrosis factor-α monoclonal antibody showed a synergistic effect on mouse CIA. Moreover, therapeutic treatment with Y-320 (0.3 and 1 mg/kg orally) ameliorated CIA in cynomolgus monkeys [1].

 

[1]. Ushio H, et al. A new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys. Pharmaceuticals (Basel). 2013 Dec 23;7(1):1-17.


Related Products :
Traxoprodil (CP-101606)
Traxoprodil (CP-101606)
Price: 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
Netobimin
Netobimin
Price: 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
HMN-154
HMN-154
Price: 200mg, $950;500mg, $1695; 1g, $2490; 2g, $3590
Eliglustat tartrate
Eliglustat tartrate
Price: 200mg, $459;500mg, $850; 1g, $1195; 2g, $1795
VGX-1027 (Synonyms: GIT 27)
VGX-1027 (Synonyms: GIT 27)
Price: 200mg, $659;500mg, $1150; 1g, $1595; 2g, $2355
P7C3
P7C3
Price: 200mg, $659;500mg, $1150; 1g, $1595; 2g, $2355
CP 640186
CP 640186
Price: 200mg, $950;500mg, $1695; 1g, $2490; 2g, $3590
TAPI-1
TAPI-1
Price: 200mg, $1250;500mg, $2090; 1g, $2995; 2g, $4395