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Product name : Y320
Item : CR1813
Price : 100mg, $845; 200mg, $1285
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CAS : 288250-47-5
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Details:
 Chemical Information
M.Wt 505.01 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C27H29ClN6O2
CAS No 288250-47-5
Solubility

DMSO



Biological Activity of Y-320

 

Y-320 is a new phenylpyrazoleanilide immunomodulator; inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM.
IC50 value: 20-60 nM (IL-17 production) [1]
Target: IL-17
Y-320 inhibited IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM. Oral administration of Y-320 (0.3 to 3 mg/kg) significantly inhibited the development and progression of arthritis and joint destruction with reduction of IL-17 mRNA expression in arthritic joints of type II collagen-induced arthritis (CIA) in DBA/1J mice. Y-320 in combination with anti-murine tumor necrosis factor-α monoclonal antibody showed a synergistic effect on mouse CIA. Moreover, therapeutic treatment with Y-320 (0.3 and 1 mg/kg orally) ameliorated CIA in cynomolgus monkeys [1].

 

[1]. Ushio H, et al. A new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys. Pharmaceuticals (Basel). 2013 Dec 23;7(1):1-17.


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