Favorite  |  Set Home
Products > Others > > Y320
Product name : Y320
Item : CR1813
Price : 100mg, $845; 200mg, $1285
contact : Send inquiry to: info@acesobio.com
Additional Information :  We offer significant discount for bulky quantity order,Please ask price and availability of other quantities
CAS : 288250-47-5
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
 Chemical Information
M.Wt 505.01 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C27H29ClN6O2
CAS No 288250-47-5
Solubility

DMSO



Biological Activity of Y-320

 

Y-320 is a new phenylpyrazoleanilide immunomodulator; inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM.
IC50 value: 20-60 nM (IL-17 production) [1]
Target: IL-17
Y-320 inhibited IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM. Oral administration of Y-320 (0.3 to 3 mg/kg) significantly inhibited the development and progression of arthritis and joint destruction with reduction of IL-17 mRNA expression in arthritic joints of type II collagen-induced arthritis (CIA) in DBA/1J mice. Y-320 in combination with anti-murine tumor necrosis factor-α monoclonal antibody showed a synergistic effect on mouse CIA. Moreover, therapeutic treatment with Y-320 (0.3 and 1 mg/kg orally) ameliorated CIA in cynomolgus monkeys [1].

 

[1]. Ushio H, et al. A new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys. Pharmaceuticals (Basel). 2013 Dec 23;7(1):1-17.


Related Products :
CM 346(Afobazol)
CM 346(Afobazol)
Price: 100mg, $945; 200mg, $1485
QS 11
QS 11
Price: 10mg, $95, 50mg, $375; 100mg, $655; 200mg, $1295
FPH2 (BRD-9424)
FPH2 (BRD-9424)
Price: 100mg, $595; 200mg, $1095;
Acitazanolast (WP 871)
Acitazanolast (WP 871)
Price: 10mg, $195; 50mg, $645; 100mg, $995; 200mg, $1955
ARRY-543
ARRY-543
Price: 100mg, $845; 200mg, $1285
P005672
P005672
Price: 10mg, $195; 50mg, $595; 100mg, $995; 200mg, $1695
Teneligliptin
Teneligliptin
Price: 500g, $845; 1g, $1485
Plerixafor (DB 06809, Mozobil, AMD 3100)
Plerixafor (DB 06809, Mozobil, AMD 3100)
Price: 10mg, $95, 50mg, $295; 100mg, $475; 200mg, $695