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Product name : HS-173
Item : CR1811
Price : 200mg, $945;500mg, $1485
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Additional Information :  We offer significant discount for bulky quantity order,Please ask price and availability of other quantities
CAS : 1276110-06-5
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Details:
 Name: HS-173

CAS#: 1276110-06-5

Chemical Formula: C21H18N4O4S
Exact Mass: 422.10488
Molecular Weight: 422.46
Elemental Analysis: C, 59.70; H, 4.29; N, 13.26; O, 15.15; S, 7.59


Description of  HS-173:  HS-173 is a potent PI3Kα inhibitor with potential anticancer activity. HS-173 inhibited the PI3K signaling pathway, and showed anti-proliferative effects on cancer cells. Also, HS-173 induced cell cycle arrest at the G(2)/M phase and apoptosis. In addition, HS-173 decreased the expression HIF-1α and VEGF which play an important role in angiogenesis. This effect was confirmed by the suppression of tube formation and migration assay in vitro. Furthermore, HS-173 diminished blood vessel formation in the Matrigel plug assay in mice. Therefore, HS-173 is considered as a novel drug candidate to treat cancer patients.



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