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Product name : ABT333
Item : CR1807
Price : 200mg, $945; 500mg, $1485
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Additional Information :  We offer significant discount for bulky quantity order,Please ask price and availability of other quantities
CAS : 1132935-63-7
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Details:
 Chemical Information
M.Wt 493.57 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C26H27N3O5S
CAS No 1132935-63-7
Solubility

DMSO



Biological Activity of ABT-333

 

ABT-333 is an NS5B non-nucleoside polymerase inhibitor.
IC50 value:
Target: HCV NS5B
in vitro:
in vivo: All patients received ABT-333 (400 mg twice daily) and ribavirin (1000 to 1200 mg per day) and one of two daily doses of ABT-450/r. Groups 1 and 2 included previously untreated patients; group 1 received 250 mg of ABT-450 and 100 mg of ritonavir, and group 2 received 150 mg and 100 mg, respectively. Group 3, which included patients who had had a null or partial response to previous therapy with peginterferon and ribavirin, received daily doses of 150 mg of ABT-450 and 100 mg of ritonavir [1]. An interferon-free combination of the protease inhibitor ABT-450 with ritonavir (ABT-450/r), the nonnucleoside polymerase inhibitor ABT-333, and ribavirin showed efficacy against the hepatitis C virus (HCV) in a pilot study involving patients with HCV genotype 1 infection [2].


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