CK-636|442632-72-6|acesobio

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Product name : CK-636

Item : CR1794

Price : 200mg, $659;500mg, $1150; 1g, $1595; 2g, $2355

contact : Send inquiry to: info@acesobio.com

CAS : 442632-72-6

Molecular Weight : 284.38

Formula : C₁₆H₁₆N₂OS

Storage : at -20°C

Additional information : We offer significant discount for bulky quantity order

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Details:

Chemical Information

M.Wt	284.38	Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Formula	C16H16N2OS
CAS No	442632-72-6
Solubility	DMSO

Biological Activity of CK-636

CK-636(CK-0944636) is a small molecule inhibitor of Arp2/3 complex; Inhibitor of actin polymerization; Cell permeable inhibitor of human (IC50=4μM), fission yeast (IC50=24μM) and bovine (IC50=32μM) Arp2/3 complex between Arp2 and Arp3. Inhibits actin polymerization (IC50=22μM).
IC50 value: 4/24/32 uM (Human/fission yeast/bovine Arp2/3) [1]
Target: Arp2/3 complex; actin polymerization
CK-636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation. CK-636 inserts into the hydrophobic core of Arp3 and alters its conformation. Both classes of compounds inhibit formation of actin filament comet tails by Listeria and podosomes by monocytes.