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Product name : CK-636
Item : CR1794
Price : 200mg, $845; 500mg, $1485
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CAS : 442632-72-6
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Details:
 Chemical Information
M.Wt 284.38 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C16H16N2OS
CAS No 442632-72-6
Solubility

DMSO



Biological Activity of CK-636

 

CK-636(CK-0944636) is a small molecule inhibitor of Arp2/3 complex; Inhibitor of actin polymerization; Cell permeable inhibitor of human (IC50=4μM), fission yeast (IC50=24μM) and bovine (IC50=32μM) Arp2/3 complex between Arp2 and Arp3. Inhibits actin polymerization (IC50=22μM).
IC50 value: 4/24/32 uM (Human/fission yeast/bovine Arp2/3) [1]
Target: Arp2/3 complex; actin polymerization
CK-636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation. CK-636 inserts into the hydrophobic core of Arp3 and alters its conformation. Both classes of compounds inhibit formation of actin filament comet tails by Listeria and podosomes by monocytes.

 

[1]. Nolen BJ, et al. Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature. 2009 Aug 20;460(7258):1031-4.


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