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Product name : GSK1292263
Item : cc-482
Price : 200mg, $850;500mg, $1450; 1g $2250; 2g, $3350
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1032823-75-8
Molecular Weight : 456.56
Formula : C₂₃H₂₈N₄O₄S
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
GSK 1292263 is a novel GPR119 receptor agonist that is currently under development for the treatment of type 2 diabetes. Treatment of male Sprague-Dawley rats with a single dose of GSK-1292263 (3-30 mg/kg) in the absence of nutrients correlated with increased levels of circulating gastrointestinal peptides; glucagon-like peptide 1 (GLP-1), gastric inhibitory polypeptide (GIP), peptide YY (PYY) and glucagon. Following administration of glucose in the oral glucose tolerance test (OGTT), greater increases in total GLP-1, GIP and PYY were seen in GSK-1292263-treated rats than in control animals. In the intravenous glucose tolerance test, significant increases in the peak insulin response and insulin AUC(0-15 min) of 30-60% were reported in the GSK-1292263 treatment group, compared with values in the vehicle control cohort. This insulin upregulation correlated with a significant increase in the glucose disposal rate. [1]
 
Reference:
[1] http://clinicaltrials.gov/ct2/show/NCT01101568.
 
 
Chemical Information
Molecular Weight (WM):
456.56
Formula:
C23H28N4O4S
CAS No:
1032823-75-8, 1032824-54-6 (HCl)
Purity:
≥ 98%
Synonyms:
GSK-1292263, GSK1292263
 
DMSO ≥ 23 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol ≥ 2 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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