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Product name : MSC2530818
Item : C2470
Price : 200mg, $1250;500mg, $2090; 1g, $2995; 2g, $4395
contact : Send inquiry to: info@acesobio.com
CAS : 1883423-59-3
Molecular Weight : 340.811
Formula : C18H17ClN4O
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order.
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Details:
Description of:MSC2530818(CAS:1883423-59-3)
MSC2530818 is a Potent, Selective, and Orally Bioavailable CDK8 Inhibitor with CDK8 IC50 = 2.6 nM; Human PK prediction: Cl ~ 0.14 L/H/Kg; t1/2 ~ 2.4h; F > 75%. MSC2530818 displays excellent kinase selectivity, biochemical and cellular potency, microsomal stability, and is orally bioavailable. MSC2530818 demonstrates suitable potency and selectivity to progress into preclinical in vivo efficacy and safety studies.

Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data. 

REFERENCES

1: Czodrowski P, Mallinger A, Wienke D, Esdar C, Poeschke O, Busch M, Rohdich F, 
Eccles SA, Ortiz Ruiz MJ, Schneider R, Raynaud FI, Clarke PA, Musil D, Schwarz D, 
Dale TC, Urbahns K, Blagg J, Schiemann K. Structure-based optimization of potent, 
selective and orally bioavailable CDK8 inhibitors discovered by high throughput 
screening. J Med Chem. 2016 Aug 4. [Epub ahead of print] PubMed PMID: 27490956.

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