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Product name : ISCK03
Item : c2421
Price : 200mg, $750;500mg, $1290; 1g, $1990; 2g, $2995
contact : Send inquiry to: info@acesobio.com
CAS : 945526-43-2
Molecular Weight : 355.456
Formula : C19H21N3O2S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order.
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Description of:ISCK03(cas:945526-43-2)
ISCK03 is a specific SCF/c-Kit inhibitor.ISCK03 inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs. ISCK03 also inhibited p44/42 ERK mitogen-activated protein kinase (MAPK) phosphorylation, which is known to be involved in SCF/c-kit downstream signaling. ISCK03 might be used as skin-whitening agents.

Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data. 


1: Na YJ, Baek HS, Ahn SM, Shin HJ, Chang IS, Hwang JS. 
[4-t-butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits 
SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin 
production in mice and brownish guinea pigs. Biochem Pharmacol. 2007 Sep 
1;74(5):780-6. Epub 2007 Jun 14. PubMed PMID: 17658483.

2: Kamlah F, Hänze J, Arenz A, Seay U, Hasan D, Juricko J, Bischoff B, Gottschald 
OR, Fournier C, Taucher-Scholz G, Scholz M, Seeger W, Engenhart-Cabillic R, Rose 
F. Comparison of the effects of carbon ion and photon irradiation on the 
angiogenic response in human lung adenocarcinoma cells. Int J Radiat Oncol Biol 
Phys. 2011 Aug 1;80(5):1541-9. doi: 10.1016/j.ijrobp.2011.03.033. Epub 2011 May 
27. PubMed PMID: 21621345.

3: Hirano T, Yoshikawa R, Harada H, Harada Y, Ishida A, Yamazaki T. Long 
noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation 
of KIT expression. Mol Cancer. 2015 Apr 19;14:90. doi: 10.1186/s12943-015-0364-7. 
PubMed PMID: 25928165; PubMed Central PMCID: PMC4423487.

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