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Product name : CB-839
Item : c2361
Price : 200mg, $950;500mg, $1695; 1g, $2490; 2g, $3590
contact : Send inquiry to: info@acesobio.com
CAS : 1439399-58-2
Molecular Weight : 571.57
Formula : C26H24F3N7O3S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order.
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Description of:CB-839
CB-839(CAS:1439399-58-2)an is orally bioavailable inhibitor of glutaminase, with potential antineoplastic activity.
CB-839 has increased potency and distinct kinetic behavior, exhibiting a slow-on/slow-off mechanism. CB-839 has a potent effect on the proliferation of HCC1806 and MDA-MB-231 cell lines (IC50 of 20-55 nM associated with cell loss at >100 nM). TNBC cell lines are sensitive to glutaminase inhibition with CB-839.

Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data. 


[1]. Gross MI, et al. Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer. Mol Cancer Ther. 2014 Apr;13(4):890-901.
[2]. Reisz JA, et al. Red blood cells in hemorrhagic shock: a critical role for glutaminolysis in fueling alanine transamination in rats. Blood Adv. 2017 Jul 14;1(17):1296-1305.
[3]. Gregory MA, et al. Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia. Exp Hematol. 2017 Sep 22. pii: S0301-472X(17)30776-2.

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