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Product name : Maraviroc (UK-427857)
Item : cc57
Price : 200mg, $1250;500mg, $2090; 1g $2995; 2g, $4395
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 376348-65-1
Molecular Weight : 513.67
Formula : C₂₉H₄₁F₂N₅O
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
Maraviroc (Selzentry, Celsentri) is an entry inhibitor. Specifically, maraviroc is a negative allosteric modulator of the CCR5 receptor, which is found on the surface of certain human cells. The chemokine receptor CCR5 is an essential co-receptor for most HIV strains and necessary for the entry process of the virus into the host cell. The drug binds to CCR5, thereby blocking the HIV protein gp120 from associating with the receptor. HIV is then unable to enter human macrophages and T-cells. Because HIV can also use other coreceptors, such as CXCR4, an HIV tropism test such as a trofile assay must be performed to determine if the drug will be effective. [1][2]
 
Reference:
[1] Br.J Clin. Pharmacol. 2008, 1,60-67.
[2] Antivir. Ther. 2009, 14, 607-618.
 
 
Chemical Information
Molecular Weight (WM):
513.67
Formula:
C29H41F2N5O
CAS No:
376348-65-1
Purity:
≥ 98%
Synonyms:
UK-427857, UK427857,UK 427857
 
DMSO ≥ 103 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 103 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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