Favorite  |  Set Home
Products > GPCR > S1P > Fingolimod (FTY720)
Product name : Fingolimod (FTY720)
Item : cc329
Price : 100mg, $65; 200mg, $110; 1g, $390
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
 Enlarge Image                   Back
            


Details:
FTY720 (Fingolimod, Gilenya) is a sphingosine-1-phosphate (S1P) receptor antagonist with IC50 of 0.033 nM. The inhibitory effect of S1P is revered by various concentrations of FTY720, with IC50 effect of 173 nM. In addition, FTY720 (10 nM) alone exerts no effect on the expression of co-stimulatory molecules. FTY720 reverses the increased expression of HLA-I induced by S1P for both the percentages of cells and the MFI, upon comparing the effect of S1P to the effect of combining S1P with FTY720. [1][2]
  
Reference:
[1] Int. J Mol. Med. 2012, 30, 211-219.
[2] Transpl. Immunol. 2001, 8, 267-277.
 
 
Chemical Information
Molecular Weight (WM):
343.93
Formula:
C28H31N5O
CAS No:
162359-56-0, 162359-55-9 (free base), 1227170-83-3 (acetate)
Purity:
≥ 98%
Synonyms:
Gilenia, FTY-720, FTY 720
 
DMSO ≥ 69 mg/mL
Solubility (25℃)
Water ≥ 69 mg/mL
 
Ethanol ≥ 69 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

Related Products :