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Product name : Nolatrexed (AG 337)
Item : cc289
Price : 10mg, $195; 50mg, $595; 100mg, $895; 200mg, $1355
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CAS : 
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Details:
Nolatrexed (AG-337), inhibits purified recombinant human thymidylate synthase (TS) with a Ki of 11 nM, and displays non-competitive inhibition kinetics. It was further shown to inhibit cell growth in a panel of cell lines of murine and human origin, displaying an IC50 of between 0.39 microM 6.6 microM. TS was suggested as the locus of action of AG-337 by the ability of thymidine to antagonize cell growth inhibition and the direct demonstration of TS inhibition in whole cells using a tritium release assay.  [1][2]
 
Reference:
[1] Clin. Caner Res. 1995, 1, 1275-1284.
[2] Caner Chemother. Pharmacol. 1996, 37, 509-517.
 
 
Chemical Information
Molecular Weight (WM):
357.258
Formula:
C14H14Cl2N4OS
CAS No:
152946-68-4, 147149-76-6
Purity:
≥ 98%
Synonyms:
AG337
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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