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Product name : Etravirine (TMC 125)
Item : cc89
Price : 10mg, $125; 50mg, $495; 100mg, $695; 200mg, $995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Etravirine (TMC-125) is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI), designed to be active against HIV with mutations that confer resistance to the two most commonly prescribed first-generation NNRTIs, mutation K103N for efavirenz and Y181C for nevirapine. This potency appears to be related to etravirine's flexibility as a molecule. Etravirine is a diarylpyrimidine (DAPY), a type of organic molecule with some conformational isomerism that can bind the enzyme reverse transcriptase in multiple conformations, allowing for a more robust interaction between etravirine and the enzyme, even in the presence of mutations. [1][2]
 
Reference:
[1] Eur. J Med. Res. 2007, 12, 483-495.
[2] J Med. Chem. 2004, 47, 2550-2560.
 
 
Chemical Information
Molecular Weight (WM):
435.28
Formula:
C20H15BrN6O
CAS No:
269055-15-4
Purity:
≥ 98%
Synonyms:
Intelence, TMC125
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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