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Products > MAPK > JNK > CC 401
Product name : CC 401
Item : cc-463
Price : 200mg, $750;500mg, $1350; 1g $1950; 2g, $3150
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 395104-30-0
Molecular Weight : 388.47
Formula : C₂₂H₂₄N₆O
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
CC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity. Based on the chemistry of SP600125, another anthrapyrazolone inhibitor of JNK, CC-401 competitively binds the ATP binding site of JNK, resulting in inhibition of the phosphorylation of the N-terminal activation domain of transcription factor c-Jun; decreased transcription activity of c-Jun; and a variety of cellular effects including decreased cellular proliferation.[1][2]

Reference:
[1] J Hepatol 2005, 42, 850-859.
[2] J Am. Soc. Nephrol. 2007, 18, 472-284.
                                        
Chemical Information
Molecular Weight (WM):
424.93
Formula:
C22H25ClN6O
CAS No:
395104-30-0
Purity:
≥ 98%
Synonyms:
CC401, CC 401
 
DMSO N/A
Solubility: (R.T.: 25℃):
Water N/A
 
Ethanol N/A
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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