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Products > Transmembrane Transporter > Proton Pump > Bafilomycin A1
Product name : Bafilomycin A1
Item : cc 710
Price : out of stock
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 88899-55-2
Molecular Weight : 622.83
Formula : C₃₅H₅₈O₉
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
Bafilomycin A1 is a highly potent vacuolar H+-ATPase inhibitor with IC50 of 0.44 nM. Bafilomycin A1 is selective for v-ATPase over other ATP hydrolyzing enzymes such as F-ATPases and the H+/K+-ATPase (P-ATPase). It is thought to inhibit autophagy either by blocking autophagosome-lysosome fusion (in H4IIE cells), or by blocking lysosomal degradation.[1][2]
 
Reference:
[1] Mol. Microbiol. 1993, 7, 323-327.
[2] J Biol Chem. 1991, 266, 17707-17712.
                                                                              
 
Chemical Information
Molecular Weight (WM):
622.83
Formula:
C35H58O9
CAS No:
88899-55-2 
Purity:
≥ 98%
Synonyms:
 
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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