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Product name : INCB8761(PF-4136309)
Item : CR1861
Price : 100mg, $1445; 200mg, $2485
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Additional Information :  We offer significant discount for bulky quantity order,Please ask price and availability of other quantities
CAS : 1341224-83-6
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 Chemical Information
M.Wt 568.59 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C29H31F3N6O3
CAS No 1341224-83-6


Biological Activity of INCB8761(PF-4136309)


INCB8761(PF-4136309) is a Potent, Selective, and Orally Bioavailable CCR2 Antagonist.


1 . Discovery of INCB8761/PF-4136309, a Potent, Selective, and Orally Bioavailable CCR2 Antagonist By Xue, Chu-Biao; Wang, Anlai; Han, Qi; Zhang, Yingxin; Cao, Ganfeng; Feng, Hao; Huang, Taisheng; Zheng, Changsheng; Xia, Michael; Zhang, Ke; et ACS Med. Chem. Lett., 2011, 2 (12), pp 913-918
We report the discovery of a new (S)-3-aminopyrrolidine series of CCR2 antagonists. Structure-activity relationship studies on this new series led to the identification of 17 (INCB8761/PF-4136309) that exhibited potent CCR2 antagonistic activity, high selectivity, weak hERG activity, and an excellent in vitro and in vivo ADMET profile. INCB8761/PF-4136309 has entered human clinical trials."

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