Favorite  |  Set Home
Products > Apoptosis > PKD > CID 755673
Product name : CID 755673
Item : CR1832
Price : 100mg, $745; 200mg, $1185
contact : Send inquiry to: info@acesobio.com
Additional Information :  We offer significant discount for bulky quantity order,Please ask price and availability of other quantities
CAS : 521937-07-5
 Enlarge Image                   Back
            


Details:
 Chemical Information
M.Wt 217.22 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C12H11NO3
CAS No 521937-07-5
Solubility

DMSO



Biological Activity of CID755673

 

CID755673 is a potent and selective cell-active small molecule inhibitor for PKD with an IC50 of 182 nM; exhibits selective PKD1 inhibition when compared with AKT, PLK1, CAK, CAMKIIα, and PKC isoforms.
IC50 value: 182 nM [1]
Target: PKD
in vitro: In cell-based assays, CID755673 blocked phorbol ester-induced endogenous PKD1 activation in LNCaP cells in a concentration-dependent manner. CID755673 inhibited the known biological actions of PKD1 including phorbol ester-induced class IIa histone deacetylase 5 nuclear exclusion, vesicular stomatitis virus glycoprotein transport from the Golgi to the plasma membrane, and the ilimaquinone-induced Golgi fragmentation [1]. PKD/PKD1 inhibition by CID755673 significantly ameliorated necrosis and severity of pancreatitis in an in vivo experimental model of acute pancreatitis [2].  Treatment with CK59 and CID755673 indeed resulted in a significant dose-dependent reduction of NK cell degranulation markers and cytokine release in freshly isolated Peripheral blood mononuclear cell populations from healthy blood donors [3].

 

[1]. Sharlow ER, et al. Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone. J Biol Chem. 2008 Nov 28;283(48):33516-26.

[2]. Yuan J, et al. Protein kinase d regulates cell death pathways in experimental pancreatitis. Front Physiol. 2012 Mar 27;3:60.

[3]. Scheiter M, et al. Protein Kinase Inhibitors CK59 and CID755673 Alter Primary Human NK Cell Effector Functions. Front Immunol. 2013 Mar 18;4:66.


Related Products :