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Product name : erastin
Item : CR1806
Price : 200mg, $745; 500mg, $1285
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CAS : 571203-78-6
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 Chemical Information
M.Wt 547.04 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C30H31ClN4O4
CAS No 571203-78-6


Biological Activity of Erastin


Erastin is a compound that interacts with VDAC, blocked and reversed mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized tubulin-induced VDAC blockage in planar bilayers.
IC50 Value: 0.1 uM (VDAC-2) [1]
Target: VDAC-2
Voltage-dependent anion channels are a class of porin ion channel located on the outer mitochondrial membrane. This major protein of the outer mitochondrial membrane of eukaryotes forms a voltage-dependent anion-selective channel (VDAC) that behaves as a general diffusion pore for small hydrophilic molecules. erastininduced RAS-RAF-MEK-dependent non-apoptotic cell death via VDAC2 [2].

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