Biological Activity of Erastin

Erastin is a compound that interacts with VDAC, blocked and reversed mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized tubulin-induced VDAC blockage in planar bilayers.
IC50 Value: 0.1 uM (VDAC-2) [1]
Target: VDAC-2
Voltage-dependent anion channels are a class of porin ion channel located on the outer mitochondrial membrane. This major protein of the outer mitochondrial membrane of eukaryotes forms a voltage-dependent anion-selective channel (VDAC) that behaves as a general diffusion pore for small hydrophilic molecules. erastininduced RAS-RAF-MEK-dependent non-apoptotic cell death via VDAC2 [2].