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Product name : NT157 (Synonyms: Tyrphostin NT157)
Item : C2483
Price : 200mg, $1250;500mg, $2090; 1g, $2995; 2g, $4395
contact : Send inquiry to: info@acesobio.com
CAS : 1384426-12-3
Molecular Weight : 412.26
Formula : C₁₆H₁₄BrNO₅S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order.
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Description of:NT157 (Synonyms: Tyrphostin NT157)
NT157(CAS: 1384426-12-3)is a selective inhibitor of IRS-1/2. NT157 significantly affected the cells' migratory ability. NT-157 induced cytostatic effects, as evidenced by G2/M cell cycle arrest, and did not affect apoptosis. NT157 has the potential to inhibit IGF-1R and STAT3 signaling pathways in cancer cells and stroma cells of TME leading to a decrease in cancer cell survival.

Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data. 


1: Rampias T, Favicchio R, Stebbing J, Giamas G. Targeting tumor-stroma 
crosstalk: the example of the NT157 inhibitor. Oncogene. 2016 May 
19;35(20):2562-4. doi: 10.1038/onc.2015.392. Epub 2015 Oct 19. PubMed PMID: 

2: Sanchez-Lopez E, Flashner-Abramson E, Shalapour S, Zhong Z, Taniguchi K, 
Levitzki A, Karin M. Targeting colorectal cancer via its microenvironment by 
inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling. 
Oncogene. 2016 May 19;35(20):2634-44. doi: 10.1038/onc.2015.326. Epub 2015 Sep 
14. PubMed PMID: 26364612; PubMed Central PMCID: PMC4791217.

3: Flashner-Abramson E, Klein S, Mullin G, Shoshan E, Song R, Shir A, Langut Y, 
Bar-Eli M, Reuveni H, Levitzki A. Targeting melanoma with NT157 by blocking Stat3 
and IGF1R signaling. Oncogene. 2016 May 19;35(20):2675-80. doi: 
10.1038/onc.2015.229. Epub 2015 Jun 29. PubMed PMID: 26119932.

4: Garofalo C, Capristo M, Mancarella C, Reunevi H, Picci P, Scotlandi K. 
Preclinical Effectiveness of Selective Inhibitor of IRS-1/2 NT157 in Osteosarcoma 
Cell Lines. Front Endocrinol (Lausanne). 2015 May 13;6:74. doi: 
10.3389/fendo.2015.00074. eCollection 2015. PubMed PMID: 26029165; PubMed Central 
PMCID: PMC4429561.

5: Ibuki N, Ghaffari M, Reuveni H, Pandey M, Fazli L, Azuma H, Gleave ME, 
Levitzki A, Cox ME. The tyrphostin NT157 suppresses insulin receptor substrates 
and augments therapeutic response of prostate cancer. Mol Cancer Ther. 2014 
Dec;13(12):2827-39. doi: 10.1158/1535-7163.MCT-13-0842. Epub 2014 Sep 29. PubMed 
PMID: 25267499.

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