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Product name : BFH772
Item : c2399
Price : 200mg, $950;500mg, $1695; 1g, $2490; 2g, $3590
contact : Send inquiry to: info@acesobio.com
CAS : 890128-81-1
Molecular Weight : 439.39
Formula : C₂₃H₁₆F₃N₃O₃
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
Description of:BFH772(cas:890128-81-1)
BFH772 is a potent oral VEGFR2 inhibitor, which is highly effective at targeting VEGFR2 kinase with an IC50 value of 3 nM.
BFH772 is highly effective at targeting VEGFR2 kinase with an IC50 value of 3 nM. BFH772 inhibits the ligand induced autophosphorylation of RET, PDGFR, and KIT kinases, with IC50 values ranging between 30 and 160 nM.

Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data. 

REFERENCES

A Novel Potent Oral Series of VEGFR2 Inhibitors Abrogate Tumor Growth by Inhibiting Angiogenesis 
Guido Bold, Christian Schnell, Pascal Furet, Paul McSheehy, Josef Brüggen, Jürgen Mestan, Paul W. Manley, Peter Drückes, Marion Burglin, Ursula Dürler, Jacqueline Loretan, Robert Reuter, Markus Wartmann, Andreas Theuer, Beatrice Bauer-Probst, Georg Martiny-Baron, Peter Allegrini, Arnaud Goepfert, Jeanette Wood, and Amanda Littlewood-Evans 
Publication Date (Web): December 2, 2015 (Article) 
DOI: 10.1021/acs.jmedchem.5b01582

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