Apoptosis
Aminopeptidase
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Product name : ND-646
Item : c2366
Price : 200mg, $1750;500mg, $2890; 1g, $4150;
contact : Send inquiry to: info@acesobio.com
CAS : 1434639-57-2
Molecular Weight : 568.64
Formula : C28H32N4O7S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order.
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| Details: |
Description of:ND-646
ND-646(CAS:1434639-57-2)is an orally bioavailable and steric inhibitor of acetyl-CoA carboxylase (ACC) with IC50s of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively.Chronic ND-646 treatment of xenograft and genetically engineered mouse models of NSCLC inhibited tumor growth. When administered as a single agent or in combination with the standard-of-care drug carboplatin, ND-646 markedly suppressed lung tumor growth in the Kras;Trp53-/- (also known as KRAS p53) and Kras;Stk11-/- (also known as KRAS Lkb1) mouse models of NSCLC. ND-646 had enhanced efficacy when combined with carboplatin, a common component of chemotherapeutic regimens used to treat human NSCLC. Quality control data: Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS. Product will be shipped with supporting analytical data. REFERENCES[1]. Svensson RU, et al. Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models. Nat Med. 2016 Oct;22(10):1108-1119. |
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