Product name : KU 57788 (NU 7441)
Item : cc207
Price : 200mg, $650;500mg, $1050; 1g $1650; 2g, $2450
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 503468-95-9
Molecular Weight : 413.49
Formula : C₂₅H₁₉NO₃S
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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NU 7441(KU 57788) is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (IC50 values are 14, 1700, 5000, >100000 and >100000 nM for DNA-PK, mTOR, PI 3-K, ATM and ATR respectively). NU 7441(KU 57788) displays no activity at a range of 60 diverse kinases at 10 μM. Potentiates the effects of radiation, doxorubicin and etoposide in human tumor cell lines in vitro and etoposide in a human tumor xenograft model in vivo. [1][2]
Reference:
[1] Bioorg. Med. Chem. Lett. 2004, 14, 6083-6087.
[2] Clin. Caner Res. 2006, 14, 3984.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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