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Product name : KU 57788 (NU 7441)
Item : cc207
Price : 10mg, $95, 50mg, $295; 100mg, $525; 200mg, $925
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Additional Information : We offer significant discount for larger quantity order
CAS : 
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Details:
NU 7441(KU 57788) is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (IC50 values are 14, 1700, 5000, >100000 and >100000 nM for DNA-PK, mTOR, PI 3-K, ATM and ATR respectively). NU 7441(KU 57788) displays no activity at a range of 60 diverse kinases at 10 μM. Potentiates the effects of radiation, doxorubicin and etoposide in human tumor cell lines in vitro and etoposide in a human tumor xenograft model in vivo. [1][2]
 
Reference:
[1] Bioorg. Med. Chem. Lett. 2004, 14, 6083-6087.
[2] Clin. Caner Res. 2006, 14, 3984.
 
 
Chemical Information
Molecular Weight (WM):
413.49
Formula:
C25H19NO3S
CAS No:
503468-95-9
Purity:
≥ 98%
Synonyms:
KU57788, KU-57788
 
DMSO ≥ 5 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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