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Products > PI3K/Akt/mTOR > PDK-1 > OSU 03012 (N/NAAR-12)
Product name : OSU 03012 (N/NAAR-12)
Item : cc115
Price : 10mg, $90; 50mg, $350; 100mg, $595; 200mg,$895
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
OSU-03012 is a recently licensed novel derivative of the cyclooxygenase-2 (COX-2) inhibitor celecoxib (CelebrexTM). However, OSU03012 lacks COX-2 inhibitory activity. It potently induces apoptosis in several types of cancer cells.The mechanism is mediated, at least in part, through the inhibition of phosphoinositide-dependent kinase-1 (PDK-1) with an IC50 of 5 μM, an upstream kinase that phosphorylates AKT. [1][2]
 
Reference:
[1] Eur. J Cancer 2009, 45, 1709-1720.
[2] Leu. Res. 2010, 34, 816-820.
 
 
Chemical Information
Molecular Weight (WM):
460.45
Formula:
C26H19F3N4O
CAS No:
742112-33-0
Purity:
≥ 98%
Synonyms:
N/AAR-12, OSU 03012, N/AAR12
 
DMSO ≥ 92 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 8 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 
 

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