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Product name : PS48
Item : CR1819
Price : 100mg, $845; 200mg, $1285
contact : Send inquiry to: info@acesobio.com
Additional Information :  We offer significant discount for bulky quantity order,Please ask price and availability of other quantities
CAS : 1180676-32-7
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Details:
 Chemical Information
M.Wt 286.75 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C17H15ClO2
CAS No 1180676-32-7
Solubility

DMSO



Biological Activity of PS48

 

PS48 is a phosphoinositide-dependent protein kinase-1 (PDK1) activator with Kd value of 10.3 μM; binds exclusively to the PIF-binding pocket of PDK1, distinct from the ATP binding site.
IC50 value: 10.3 uM (Kd)
Target: PDK1 activator

 

[1]. Hindie V, et al. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat Chem Biol. 2009 Oct;5(10):758-64.

[2]. Stroba A, et al. 3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds. J Med Chem. 2009 Aug 13;52(15):4683-93.


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