Favorite  |  Set Home
Product name : PS48
Item : CR1819
Price : 100mg, $845; 200mg, $1285
contact : Send inquiry to: info@acesobio.com
Additional Information :  We offer significant discount for bulky quantity order,Please ask price and availability of other quantities
CAS : 1180676-32-7
 Enlarge Image                   Back
             [Next Product]→

 Chemical Information
M.Wt 286.75 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C17H15ClO2
CAS No 1180676-32-7


Biological Activity of PS48


PS48 is a phosphoinositide-dependent protein kinase-1 (PDK1) activator with Kd value of 10.3 μM; binds exclusively to the PIF-binding pocket of PDK1, distinct from the ATP binding site.
IC50 value: 10.3 uM (Kd)
Target: PDK1 activator


[1]. Hindie V, et al. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat Chem Biol. 2009 Oct;5(10):758-64.

[2]. Stroba A, et al. 3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds. J Med Chem. 2009 Aug 13;52(15):4683-93.

Related Products :
Price: 100mg, $500; 500mg, $1295;
OSU 03012 (N/NAAR-12)
OSU 03012 (N/NAAR-12)
Price: 200mg, $649;500mg, $1050; 1g $1595; 2g, $2355
BX 912
BX 912
Price: 200mg, $950;500mg, $1650; 1g $2450; 2g, $3650