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Product name : LY 2157299
Item : cc8
Price : 10mg, $225; 50mg, $795; 100mg, $1295; 200mg, $2195
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
LY2157299 is a potent TβRI and TβRII (transforming growth factor β receptor I and II) inhibitor with IC50 of 86 nM and 2 nM, respectively. In human glioblastoma (GBM) cells, LY-2157299 treatment blocks signaling through the heteromeric TGFβ receptor complex to reduce levels of active, phosphorylated SMAD.Most importantly, treatment with LY 2157299 stimulated hematopoiesis from primary MDS bone marrow specimens. [1][2]
 
Reference:
[1] Cancer Res. 2011, 71, 955-963.
[2] Eur. J Cancer 2008, 44, 142-150.
 
 
Chemical Information
Molecular Weight (WM):
369.42
Formula:
C22H19N5O
CAS No:
700874-72-2, 924898-09-9 (H2O)
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 74 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 9 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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