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Product name : IOX 2
Item : cc 642
Price : 10mg, $125; 50mg, $495; 100mg, $795; 200mg, $1095
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Levels of the Hypoxia Inducible Factor (HIF) are regulated by the hydroxylation of prolyl residues in oxygen-dependent degradation domains in the HIF-1α subunit. HIF prolyl hydroxylation is catalyzed by prolyl hydroxylase domain enzymes (PHD1, 2, and 3), members of the Fe(II) and 2-oxoglutarate (2OG) oxygenase family. Inhibition of the PHDs reduces HIFα prolyl-hydroxylation so elevating HIF levels and artificially inducing the hypoxic response. PHD inhibition is of considerable medical interest. 

 IOX2 is a potent inhibitor of PHD2 (IC50 = 21 nM). IOX-2 displays over 100-fold selectivity compared to inhibition of JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH (IC50s <100 μM). IOX2 is active in cells, inhibiting HIF-1α hydroxylation in RCC4 cells at 50 μM. [1][2]
 
Reference:
[1] Anal. Biochem. 2010, 86-93.
[2] J Med. Chem. 2008, 51, 7053-7056.
  
 
Chemical Information
Molecular Weight (WM):
352.34
Formula:
C19H16N2O5
CAS No:
931398-72-0
Purity:
≥ 98%
Synonyms:
IOX 2
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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