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Product name : PF-04449913
Item : CR1825
Price : 100mg, $945; 200mg, $1485
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Additional Information :  We offer significant discount for bulky quantity order,Please ask price and availability of other quantities
CAS : 1095173-27-5
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Details:
 Chemical Information
M.Wt 374.44 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C21H22N6O
CAS No 1095173-27-5
Solubility

DMSO



Biological Activity of PF-04449913

 

PF-04449913 is a potent and orally bioavailable inhibitor of smoothened with IC50 of 5 nM(Gli-luciferase reporter reporter in C3H10T1/2); the hedgehog pathway inhibitor.
IC50 value: 5 nM [1]
Target: smoothened
PF-04449913, a Smoothened inhibitor was identified possessing excellent potency and physical properties that translate to an attractive predicted human pharmacokinetic profile. PF-04449913 was advanced to in vivo tumor growth inhibition studies, preclinical safety studies, and ultimately to human clinical trials. These results will be reported in separate disclosures.

 

[1]. Michael J. Munchhof, et al. Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened. ACS Med. Chem. Lett., 2012, 3 (2), pp 106–111


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