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Product name : TAK 875
Item : cc-64
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1000413-72-8
Molecular Weight : 524.63
Formula : C₂₉H₃₂O₇S
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
TAK 875 is a potent, selective and orally bioavailable GPR40 agonist with an EC50 of 0.072 μM. TAK-875 is a new agent applied in the treatment of type 2 diabetes. TAK-875 not only elevated the levels of intra-cellular inositol monophosphate as well as calcium contents in rat insulinoma INS-1 833/15 cells but also improved the tolerance of glucose and amplified insulin secretion when orally administered in tolerance test. However, TAK-875 didn’t increase the secretion of insulin and cause hypoglycemia when 30 mg/kg dosage of TAK-875 was given in fasted normal Sprague Dawley rats. Conversely, TAK-875 with a dosage of 10 mg/kg (p.o.) not only significantly improved plasma insulin levels but also decreased fasting hyperglycemia in male Zucker diabetic fatty rats. [1][2]
  
Reference:
[1] Lancet 2012, 379, 1403-1411.
[2] Clin. Pharmacol. Ther. 2012, 92, 29-39.
 
 
Chemical Information
Molecular Weight (WM):
533.63
Formula:
C29H32O7S·1/2H2O
CAS No:
1000413-72-8
Purity:
≥ 98%
Synonyms:
TAK-875, TAK875
 
DMSO ≥ 105 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol ≥ 11 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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