IRAK-1/4

Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor is a benzimidazole compound that acts as a cell-permeable, potent selective inhibitor of IL-1 k...

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Bindarit

Bindarit, a novel molecule devoid of immunosuppressive effects, exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/...

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IRAK inhibitor 6

IRAK inhibitor 6 is interleukin-1 receptor associated kinase 4 (IRAK-4) inhibitor . [1][2] Reference: [1] J Enzyme Inhib. Med. Chem. 2010, 2...

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Macitentan (ACT 064992)

Macitentan (ACT-064992) is an investigational drug being studied for the treatment of pulmonary arterial hypertension. [1][2] Ref...

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LRRK2-IN-1

LRRK2-IN-1 is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2). LRRK2-IN-1inhibits both G2019S mutant and wild-type LRRK...

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Eltrombopag (SB-497115-GR, Promacta, Revolade)

Eltrombopag (SB-497115-GR, Promacta, Revolade) is a small molecule agonist of the c-mpl (TpoR) receptor with an IC50 of 0.69 μM for the inhibition ...

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RU 58841

Chemical Information Molecular Weight (WM): 369.34 ...

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ASC-J9 (GO-Y025, Dimethylcurcumin)

ASC-J9 could degrade both full-length (fAR) and AR3 in CWR22Rv1 cells as well as in C4-2 and C81 cells with addition of AR3. The consequences of such ...

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A 205804

A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respecti...

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AZD 0837

AZD-0837 is an investigational oral anticoagulant which is converted to the active form, AR-H067637, a selective direct thrombin inhibitor. [1][...

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VU-0364439

VU-0364439 is a potent positive allosteric modulator (PAM) of mGluR-4 (metabotropic glutamate receptor) (EC50 = 19.8 nM in vitro for human mGluR-4). [...

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MK 866

MK-866 is an inhibitor of leukotriene biosynthesis (IC50 = 3 nM in human polymorphonuclear leukocytes). MK866 inhibits 5-lipoxygenase-activating...

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Laropiprant (MK 0524)

Laropiprant (MK-0524) is a potent, selective DP1 receptor antagonist with Ki values of 0.57 nM and 0.75 µM for the DP1 and DP2 receptors, respec...

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GW 2580

GW2580 is a small-molecule, ATP-competitive inhibitor of cFMS kinase.cFMS Receptor Tyrosine Kinase Inhibitor is a selective cell-permeable diaminopyri...

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HQL 79

HQL-79 is a selective inhibitor of hematopoietic prostaglandin D (PGD) synthase with IC50 of 6 μM. Subsequent evaluation in models of allergy and a...

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LDN 192960

Chemical Information Molecular Weight (WM): 328.43 ...

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