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Product name : Ku 60019
Item : cc509
Price : 10mg, $110; 50mg, $425; 100mg, $875; 200mg, $1295
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Additional Information : We offer significant discount for larger quantity order
CAS : 
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Details:
KU 60019 is a potent and specific ATM kinase inhibitor with IC50 of 6.3 nM. Compared to KU-55933, KU-60019 is an improved more water-soluble inhibitor of the ATM kinase, while displaying similar target selectivity. KU-60019 has little activity against DNA-PKcs and ATR with IC50 values of 1.7 μM and >10 μM, respectively, as well as 229 other protein kinases such as PI3K, mTOR and mTOR/FKBP12. KU-60019 displays 3- to 10-fold more potency than KU-55933 at blocking radiation-induced phosphorylation of key ATM protein targets such as p53, γ-H2AX, and CHK2, in human glioma U87 and U1242 cells, as 1 μM of KU-60019 significantly induces >70% decrease of p53 (S15) phosphorylation to which extent ~10 μM of KU-55933 is required to achieve. [1][2]
 
Reference:
[1] Mol. Cancer. Ther. 2009, 8, 2894-2902.
[2] Cell Cycle 2012, 11, 1167-1173.
 
 
Chemical Information
Molecular Weight (WM):
547.67
Formula:
C30H33N3O5S
CAS No:
925701-49-1
Purity:
≥ 98%
Synonyms:
KU60019, KU-60019
 
DMSO ≥ 48 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 21 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 
 

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