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Product name : CP 466722
Item : cc85
Price : 10mg, $245; 50mg, $725; 100mg, $1295; 200mg, $1895
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Additional Information : We offer significant discount for larger quantity order
CAS : 
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Details:
CP 466722 is rapidly reversible potential ATM kinase inhibitor. CP-466722 is non-toxic and does not inhibit PI3K or PI3K-like protein kinase family members in cells. CP-466722 inhibited cellular ATM-dependent phosphorylation events and disruption of ATM function resulted in characteristic cell cycle checkpoint defects. Inhibition of cellular ATM kinase activity was rapidly and completely reversed by removing CP-466722. Interestingly, clonogenic survival assays demonstrated that transient inhibition of ATM is sufficient to sensitize cells to ionizing radiation and suggests that therapeutic radiosensitization may only require ATM inhibition for short periods of time. The ability of CP-466722 to rapidly and reversibly regulate ATM activity provides a new tool to ask questions about ATM function that could not easily be addressed using genetic models or RNA interference technologies.[1][2]
 
Reference:
[1] Cancer Res. 2008, 68, 7466-7474.
[2] Expert Opin. Ther. Pat. 2009, 19, 775-799.
 
 
Chemical Information
Molecular Weight (WM):
349.35
Formula:
C17H15N7O2
CAS No:
1080622-86-1
Purity:
≥ 98%
Synonyms:
CP-466722, CP466722
 
DMSO < 1 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 
 

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