Apoptosis
CCR5
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Product name : Elvitegravir (GS-9137)
Item : cc521
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 697761-98-1
Molecular Weight : 447.88
Formula : C₂₃H₂₃ClFNO₅
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Elvitegravir (GS-9137) is a human immunodeficiency virus integrase inhibitor to HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively. After HIV's genetic material is deposited inside a cell, its RNA must be converted (reverse transcribed) into DNA. A viral enzyme called integrase then helps to hide HIV's DNA inside the cell's DNA. Once this happens, the cell can begin producing genetic material for new viruses. Integrase inhibitors, such as elvitegravir, are designed to block the activity of the integrase enzyme and to prevent HIV DNA from entering healthy cell DNA. [1][2]
Reference:
[1] AIDS 2008, 22, 1877-1880.
[2] Biochemistry 2008, 47, 9345-9354.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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