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Product name : R935788 (Fostamatinib disodium)
Item : cc28
Price : 10mg, $245; 50mg, $785; 100mg, $1295; 200mg, $1895
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
R935788 (Fostamatinib disodium, R788) is a selective spleen Syk inhibitor with IC50 of 41 nM.R-935788 inhibits Syk kinase-mediated IgG Fc gamma receptor signaling, resulting in inhibition of the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. Syk kinase, widely expressed in hematopoietic cells, is a nonreceptor tyrosine kinase that is involved in coupling activated immunoreceptors to signal downstream events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis.  [1][2]
 
Reference:
[1] IDrugs 2009, 12, 174-185.
[2] J Clin. Pharmacol. 2011, 51, 1310-1318.
 
 
Chemical Information
Molecular Weight (WM):
624,42
Formula:
C23H24FN6O9P·2Na
CAS No:
1025687-58-4
Purity:
≥ 98%
Synonyms:
R-935788, R 93578, R788, R-788, R 788
 
DMSO < 1 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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