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Product name : R 406
Item : cc243
Price : 10mg, $195; 50mg, $795; 100mg,$1295; 200mg, $2155
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
R406 (free base) is a spleen tyrosine kinase (Syk) inhibitor with IC50 of 41 nM. R-406 is an ATP-competitive inhibitor of Syk with a Ki value of 30 nM. R 406 selectively inhibits Syk-dependent signaling with EC50 values ranging from 33 nM to 171 nM. R406 inhibits cellular proliferation of a large panel of diffuse large B-cell lymphoma (DLBCL) cell lines at EC50 values ranging from 0.8 μM to 8.1 μM. R406 treatment (1 μM or 4 μM) induces the activation of caspases 9 and 3, but not caspase 8, leading to significant apoptosis of the majority of DLBCL cell lines. [1][2]
 
Reference:
[1] J Pharmacol. Exp. Ther. 2006, 319, 998-1008.
[2] Leukemia 2011, 1, 1-11.
 
 
Chemical Information
Molecular Weight (WM):
470.45
Formula:
C22H23FN6O5
CAS No:
841290-80-0, 841290-81-1, 841290-82-2 (methanesulfonate)
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 29 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 94 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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