Favorite  |  Set Home
Product name : VX-765
Item : cc-448
Price : 10mg, $165; 50mg, $475; 100mg, $ 675; 200mg, $995
contact : Send enquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for larger quantity order
CAS : 
 Enlarge Image                   Back
←[Previous Product]             


Details:
VX-765 is a novel Caspase-1 inhibitor with an IC 50 of 0.8nM being investigated for the treatment of epilepsy, currently being developed by Vertex. VX-765 is an orally-absorbed prodrug of VRT-043198, a potent and selective inhibitor of ICE-caspase-1 sub-family caspases.VRT-043198 exhibits 100-10,000-fold selective against other caspase-3 and -6,-9. In cultures of peripheral blood mononuclear cells and whole blood from healthy subjects stimulated with bacterial products, VX-765 has been shown to inhibit acute partial seizures in preclinical models and has shown activity in preclinical models of chronic partial epilepsy that do not respond to currently available medicines for epilepsy. in addition, VX-765 reduced disease severity and the expression of inflammatory mediators in models of rheumatoid arthritis and skin inflammation.[1] [2]
 
Reference:
[1] JPET 2007, 321, 509-516.
[2] J. Immunol. 2005, 175, 2630-2634                                              
 
Chemical Information
Molecular Weight (WM):
509
Formula:
C24H33ClN4O6
CAS No:
273404-37-8
Purity:
≥ 98%
Synonyms:
N/A
 
DMSO ≥ 102mg/mL
Solubility: (R.T.: 25℃):
Water < 1mg/mL
 
Ethanol ≥ 102 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃         in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

Related Products :
Apoptosis Activator 2
Apoptosis Activator 2
Price: 50mg, $195; 100mg, $395; 200mg, $695, 1g, $1295
PAC-1
PAC-1
Price: 10mg, $65; 50mg, $245; 100mg, $295; 200mg, $475