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Product name : Serdemetan (JNJ 26854165)
Item : cc-450
Price : 5mg, $95; 10mg, $165; 50mg, $475; 100mg, $ 795
contact : Send enquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for larger quantity order
CAS : 
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Details:
Serdemetan (JNJ-26854165) is a novel tryptamine compound which activated p53 and acts as a HDM2 ubiquitin ligase antagonist. It inhibits cell growth and induces apoptosis in leukemia cell lines with IC50 of 0.24, 0.33, 0.32, and 0.44 μM for OCI-AML-3, MOLM-13, NALM-6 and REH cells respectively.
 
Serdemetan is and orally bioavailable, first-in-class small molecule HDM2 antagonist with potential antineoplastic activity.[1][2]
 
Reference:
[1] Cancer Lett. 2011, 312, 209-218
[2] Curr. Pharm. Des. 2011, 17, 536-539.
                                               
 
Chemical Information
Molecular Weight (WM):
328.41
Formula:
C21H20N4
CAS No:
881202-45-5, 881202-79-5 (3HCl)
Purity:
≥ 98%
Synonyms:
JNJ 26854165
 
DMSO ≥ 66 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol ≥ 2 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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