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Product name : RITA (NSC 652287)
Item : cc 648
Price : 10mg, $145; 50mg, $495; 100mg, $795; 200mg, $995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
MDM-2 is a key negative regulator of p53 that binds to and targets p53 for proteasomal degradation. Overexpression of MDM-2 in some tumors leads to inactivation of p53 thereby allowing tumor cells to escape p53-induced apotposis. p53 Activator III, RITA, also referred to as NSC 652287, binds to MDM2 (Kd = 1.5 nM), disrupting the MDM2-p53 complex and subsequently activating p53 and inducing apoptosis. [1][2]
 
Reference:
[1] Mol. Pharmacol. 1999, 56, 478-484.
[2] Nat. Med. 2004, 10, 1321-1328.
 
 
Chemical Information
Molecular Weight (WM):
292.37
Formula:
C14H12O3S2
CAS No:
213261-59-7
Purity:
≥ 98%
Synonyms:
NSC652287, NSC-652287
 
DMSO ≥ 58 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 8 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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