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Product name : Y 27632
Item : cc26
Price : 10mg, $145; 50mg, $455; 100mg, $745; 200mg, $995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Y-27632 is a selective Rho-associated protein kinase 1 (ROCK1, p160ROCK) inhibitor with Ki of 140 nM. Y27632, a selective ROCK inhibitor, inhibited ET-1-induced increases in natriuretic peptide production, cell size, protein synthesis, and myofibrillar organization. In addition, a dominant-negative mutant of p160ROCK suppressed ET-1-induced transcription of the BNP gene. These findings suggest that the Rho/ROCK pathway is an important component of ET-1-induced hypertrophic signals in cardiac myocytes. [1][2]
 
Reference:
[1] Nature 1997, 389, 990-994.
[2] Neuron 2000, 26, 431-441.
 
 
Chemical Information
Molecular Weight (WM):
320.258
Formula:
C14H21N3O·2HCl
CAS No:
146986-50-7, 129830-38-2
Purity:
≥ 98%
Synonyms:
Y 27632
 
DMSO ≥ 50 mg/mL
Solubility (25℃)
Water ≥ 50 mg/mL
 
Ethanol ≥ 12 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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