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Product name : Brequinar (DUP 785, NSC 368390)
Item : cc183
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS :  96187-53-0
Molecular Weight : 375.37
Formula : C₂₃H₁₅F₂NO₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
Brequinar (DUP-785, NSC-368390) inhibits dihydroorotate dehydrogenase (DHODH), the fourth enzyme in the de novo pyrimidine biosynthesis pathway, preventing the synthesis of DNA and RNA. Brequinar (DUP785, NSC368390) has recently been found to have antiviral activity against a broad spectrum of viruses including flaviviruses (dengue virus, West Nile virus, yellow fever virus, and Powassan virus) and also a plus-strand RNA alphavirus (Western equine encephalitis virus) and a negative-strand RNA rhabdovirus (vesicular stomatitis virus). [1][2]
 
Reference:
[1] Cancer Chemother. Pharmacol. 1988, 22, 183-186.
[2] Eur. J Cancer Clin. Oncol. 1988, 24, 1903-1904.
 
 
Chemical Information
Molecular Weight (WM):
375.37
Formula:
C23H15F2NO2
CAS No:
96187-53-0
Purity:
≥ 98%
Synonyms:
DUP 785, NSC 368390
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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