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Product name : ABT 751 (E7010)
Item : cc576
Price : 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 141430-65-1
Molecular Weight : 371.41
Formula : C₁₈H₁₇N₃O₄S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
ABT-751 (E7010) is a orally bioavailable tubulin-binding and antimitotic sulfonamide which binds to the colchicine site on ß-tubulin and inhibits polymerization of microtubules.  ABT751 (E-7010)binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of microtubules, thereby preventing tumor cell replication. This agent also disrupts tumor neovascularization, reducing tumor blood flow and so inducing a cytotoxic effect.  [1][2]
 
Reference:
[1] Pediatr. Blood Cancer 2010, 54, 47-54.
[2] Cancer Chemother. Pharmacol. 2007, 59, 725-732.
 
 
Chemical Information
Molecular Weight (WM):
371.41
Formula:
C18H17N3O4S
CAS No:
141430-65-1, 141450-48-8 (HCl)
Purity:
≥ 98%
Synonyms:
E 7010
 
DMSO ≥ 74 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 15 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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