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Product name : LY 2603618 (IC 83)
Item : cc579
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 911222-45-2
Molecular Weight : 436.3
Formula : C₁₈H₂₂BrN₅O₃
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
LY2603618 (IC83) is a highly selective Chk 1 inhibitor with potential antitumor activity. LY-2603618 (IC-83) binds to and inhibits the activity of chk1, which may prevent the repair of DNA caused by DNA-damaging agents, thus potentiating the antitumor efficacies of various chemotherapeutic agents. Chk1, an ATP-dependent serine-threonine kinase, is a key component in the DNA replication-monitoring checkpoint system and is activated by double-stranded breaks (DSBs); activated chk1 is overexpressed by a variety of cancer cell types.  [1]
 
Reference:
[1] Clin. Cancer Res. 2010, 16, 376-383.
 
 
Chemical Information
Molecular Weight (WM):
436.30
Formula:
C18H22BrN5O3
CAS No:
911222-45-2
Purity:
≥ 98%
Synonyms:
LY 2603618, IC 83
 
DMSO ≥ 21 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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