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Product name : AKP-11
Item : C2459
Price : 200mg, $1750;500mg, $2890; 1g, $3950;
contact : Send inquiry to: info@acesobio.com
CAS : 1220973-37-4
Molecular Weight : 443.88
Formula : C22H22ClN3O5
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order.
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Details:
Description of:AKP-11
AKP-11 is A Novel S1P1 Agonist with Favorable Safety Profile Attenuates Experimental Autoimmune Encephalomyelitis in Rat Model of Multiple Sclerosis. AKP-11 is the next generation of S1P1 agonist with immunomodulatory activities in cell culture model and for therapeutic efficacy against an animal model of MS, i.e. experimental autoimmune encephalomyelitis (EAE) but without the adverse effects observed with FTY720.

AKP-11 binds to S1P1 is internalized and activates intracellular AKT and ERKs cellular signaling pathways. AKP-11 mediated S1P1 downregulation is independent of sphingosine kinase activity indicating it to be a direct agonist of S1P1. AKP-11 decreases cell surface expression of S1P1 in in vitro cell culture model

Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.

REFERENCES

1: Samuvel DJ, Saxena N, Dhindsa JS, Singh AK, Gill GS, Grobelny DW, Singh I. 
AKP-11 - A Novel S1P1 Agonist with Favorable Safety Profile Attenuates 
Experimental Autoimmune Encephalomyelitis in Rat Model of Multiple Sclerosis. 
PLoS One. 2015 Oct 29;10(10):e0141781. doi: 10.1371/journal.pone.0141781. 
eCollection 2015. PubMed PMID: 26513477; PubMed Central PMCID: PMC4626178.

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