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Products > JAK/STAT > Pim Kinase > SMI-16a (Synonyms: PIM1/2 Kinase Inhibitor VI)
Product name : SMI-16a (Synonyms: PIM1/2 Kinase Inhibitor VI)
Item : c2429
Price : 200mg, $659;500mg, $1150; 1g, $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com
CAS : 587852-28-6
Molecular Weight : 263.31
Formula : C₁₃H₁₃NO₃S
Storage : at -20°C
Additional information : 
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Details:
Description of:SMI-16a(cas:587852-28-6)
SMI-16a is a selective Pim kinase inhibitor with IC50 values of 0.15, 0.02 and 48 μM for Pim1, Pim2 and PC3 cells, respectively.
SMI-16a has excellent potency for inhibition of both Pim-1 and Pim-2
[1]. Treatment with Pim-2 short-interference RNA as well as the Pim inhibitor SMI-16a successfully restores osteoblastogenesis suppressed by all the above inhibitory factors and MM cells. The SMI-16a treatment potentiates BMP-2-mediated anabolic signaling while suppressing TGF-β signaling

Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 

REFERENCES

[1]. Xia Z, et al. Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. J Med Chem. 2009 Jan 8;52(1):74-86.
[2]. Hiasa M, et al. Pim-2 kinase is an important target of treatment for tumor progression and bone loss in myeloma. Leukemia. 2015 Jan;29(1):207-17.



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