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Product name : GJ-103
Item : c2419
Price : 200mg, $750;500mg, $1290; 1g, $1990; 2g, $2995
contact : Send inquiry to: info@acesobio.com
CAS : 1459687-89-8
Molecular Weight : 342.373
Formula : C16H14N4O3S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order.
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Details:
Description of:GJ-103(cas:1459687-89-8)

GJ-103 is an active analog of the read-through compound GJ072. Chemical-induced read through of premature stop codons might be exploited as a potential treatment strategy for genetic disorders caused by nonsense mutations.

Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
  

REFERENCES

1: Du L, Jung ME, Damoiseaux R, Completo G, Fike F, Ku JM, Nahas S, Piao C, Hu H, 
Gatti RA. A new series of small molecular weight compounds induce read through of 
all three types of nonsense mutations in the ATM gene. Mol Ther. 2013 
Sep;21(9):1653-60. doi: 10.1038/mt.2013.150. Epub 2013 Jun 18. PubMed PMID: 
23774824; PubMed Central PMCID: PMC3776636.

2: Lavin MF. Generating SM(a)RTer compounds for translation termination 
suppression in A-T and other genetic disorders. Mol Ther. 2013 Sep;21(9):1650-2. 
doi: 10.1038/mt.2013.177. PubMed PMID: 24008619; PubMed Central PMCID: 
PMC3776641.


 


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