Apoptosis
DPP4
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Product name : Elesclomol (SAT 4783)
Item : cc547
Price : 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 488832-69-5
Molecular Weight : 400.52
Formula : C₁₉H₂₀N₄O₂S₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Elesclomol (STA4783) induces oxidative stress, creating high levels of reactive oxygen species (ROS), such as hydrogen peroxide, in both cancer cells and normal cells. Because tumor cells have elevated levels of ROS compared to normal cells, the increase in oxidative stress beyond baseline levels elevates ROS beyond sustainable levels, exhausting tumor cell antioxidant capacity, which may result in the induction of the mitochondrial apoptosis pathway. Normal cells are spared because the increase in the level of oxidative stress induced by this agent is below the threshold at which apoptosis is induced. [1][2]
Reference:
[1] Mol. Cancer Ther. 2008, 7, 2319-2327.
[2] J Am. Chem. Soc. 2010, 132, 5469-5478.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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