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Product name : SRT 1720
Item : cc265
Price : 10mg, $245; 50mg, $825; 100mg, $1095; 200mg, $1995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
SRT-1720 is a selective human silent information regulator 1 (SIRT1) activator with EC1.5 of 0.16 μM. This agent binds to the SIRT1 enzyme-peptide substrate complex at an allosteric site amino-terminal to the catalytic domain and lower the Michaelis constant for acetylated substrates. In diet-induced obese and genetically obese mice, SRT1720 improved insulin sensitivity, lower plasma glucose, and increase mitochondrial capacity. Thus, SR T1720 is a promising new therapeutic agent for treating diseases of ageing such as type 2 diabetes. [1][2]
 
Reference:
[1] Nature 2007, 450, 712-716.
[2] Br. J Haematol. 2011, 155, 588-598.
 
 
Chemical Information
Molecular Weight (WM):
506.02
Formula:
C25H24ClN7OS
CAS No:
1001645-58-4
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 101 mg/mL
Solubility (25℃)
Water ≥ 23 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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