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Product name : VX 770 (Ivacaftor)
Item : cc231
Price : 10mg, $195; 50mg, $675; 100mg, $965; 200mg, $1655
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Ivacaftor (VX-770) is a CFTR potentiator with an IC50 of 43 ± 38 nM. In recombinant cells Ivacaftor (VX770) increased CFTR channel open probability (P(o)) in both the F508del processing mutation and the G551D gating mutation. Ivacaftor (VX 770) also increased Cl(-) secretion in cultured human CF bronchial epithelia (HBE) carrying the G551D gating mutation on one allele and the F508del processing mutation on the other allele by approximately 10-fold, to approximately 50% of that observed in HBE isolated from individuals without CF. Furthermore,Ivacaftor (VX-770) reduced excessive Na(+) and fluid absorption to prevent dehydration of the apical surface and increased cilia beating in these epithelial cultures.Ivacaftor (VX-770) is useful for treatment of Cystic fibrosis. [1]
 
Reference:
[1] Proc. Natl. Acad. Sci. USA 2009, 106, 18825-18830.
 
 
Chemical Information
Molecular Weight (WM):
392.49
Formula:
C24H28N2O3
CAS No:
873054-44-5, 1134822-09-5 (benzenesulfonate), 1134822-07-3 (H2O)
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 79 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 4 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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